G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or inhibited by different classes of receptors, suggesting a role for G proteins in determining signaling specificity.
Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRKgirk1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.
In this chapter, we descgirkribe advances in our understanding of GIRK channel function based on recent high-resolution atomic structures of inwardly rectifying K (+) channels discussed in the context of classical structure-function experiments.
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